The area's leading online source for news!
Louisa-Lawrence Co, KY

In God We Trust - Established 2008


NIH discovery in mice could lead to new class of medications to fight mid-life obesity

Study shows that there is a genetic program driven by an overactive enzyme that promotes weight gain and loss of exercise capacity at mid-lifeStudy shows that there is a genetic program driven by an overactive enzyme that promotes weight gain and loss of exercise capacity at mid-life

A team of scientists led by researchers from the National Institutes of Health has identified an enzyme that could help in the continuous battle against mid-life obesity and fitness loss. The discovery in mice could upend current notions about why people gain weight as they age, and could one day lead to more effective weight-loss medications.

“Our society attributes the weight gain and lack of exercise at mid-life (approximately 30-60 years) primarily to poor lifestyle choices and lack of will power, but this study shows that there is a genetic program driven by an overactive enzyme that promotes weight gain and loss of exercise capacity at mid-life,” said lead study author Jay H. Chung, Ph.D., M.D., head of the Laboratory of Obesity and Aging Research at the National Heart, Lung, and Blood Institute (NHLBI), part of NIH.

Chung and his team used mice to test the potentially key role this enzyme plays in obesity and exercise capacity. They administered an inhibitor that blocked the enzyme in one group being fed high-fat foods, but withheld it in another. The result was a 40 percent decrease in weight gain in the group that received the inhibitor.

The study, the first to link the increased activity of this enzyme to aging and obesity, appears in the current issue of Cell Metabolism. Its findings could have ramifications for several chronic illnesses. With lower rates of obesity, the researchers say, rates of heart disease, diabetes, and other diseases that tend to increase with age, including cancer and Alzheimer’s disease, could fall as well.

Researchers have known for years that losing weight and maintaining the capacity to exercise tend to get harder beginning between ages 30 to 40 — the start of midlife. Scientists have developed new therapies for obesity, including fat-fighting pills. However, many of those therapies have failed because of a lack of understanding about the biological changes that cause middle-aged people to gain weight, particularly around their abdomen.

Chung, an endocrinologist, was always puzzled by the aging-weight gain paradox. An average adult in America gains 30 pounds from age 20 to 50, even though food intake usually decreases during this period. The aim of the current study was to better understand this mid-life weight gain and lowered exercise capacity.

Chung and his associates searched for biochemical changes that occurred in middle-aged animals (human equivalent of 45 years). They found that an enzyme called DNA-dependent protein kinase, or DNA-PK, increases in activity with age. Further work showed that DNA-PK promotes conversion of nutrients to fat and decreases the number of mitochondria, tiny organelles in the cells that turn fat into energy to fuel the body.

Mitochondria can be found in abundance among young people, but the numbers drop considerably in older people. Researchers know that decreased mitochondria can promote obesity as well as loss of exercise capacity.

Chung and his associates theorized that reducing DNA-PK activity may decrease fat accumulation and increase mitochondria number as well as promote fat burning. The researchers tested their theory by orally administering a drug that inhibits DNA-PK and found that, in addition to preventing weight gain in the mice, the inhibitor drug boosted mitochondrial content in skeletal muscle, increased aerobic fitness in obese and middle aged mice, and reduced the incidence of obesity and type-2 diabetes..

“Our studies indicate that DNA-PK is one of the drivers of the metabolic and fitness decline that occurs during aging, which makes staying lean and physically fit difficult and increases susceptibility to metabolic diseases like diabetes,” Chung said. “The identification of this new mechanism is very important for improving public health.”.

“The study opens the door to the development of a new type of weight-loss medication that could work by inhibiting DNA-PK activity,” Chung said. However, he notes that DNA-PK inhibitors have yet to be tested this way in humans.

In the meantime, the researchers say, middle-aged people who are fighting obesity should not abandon common practices of reducing calorie intake and boosting exercise, even if it takes a while to see results.

This study was supported by the Intramural Research Program of NHLBI, part of NIH.



Add comment

Security code

969 - Vikings: War of Clans (Desktop)
Welcome to the ruthless world of vikings, where freedom, power, fear and violence reign supreme! Become the leader of a large army, lead your troops to victory and prove that you are the mightiest conqueror among a million players.


1313 - / Craft Beer Delivered was founded in 2013 with a mission to support independent craft breweries across the country! We try thousands of beers and bring you the gems you can't get at your local store. After downloading our app, everyday you'll will get access to 2 rare beers not found in your area. Claim the beers you want and skip on the ones you don't. Get it all delivered, we will ship your hand picked craft beers to your door for one flat fee no matter how much you buy. There are no commitments to signing up or ordering monthly. Conversion process: first page submit


1289 - Credit Sesame (Incent)
Credit Sesame is a 100% free personal finance credit and debt management tool with no credit card required or trial period. Credit Sesame makes managing personal credit online, owing less in interest and saving on mortgage, loan & credit card payments easy!


470 - $500 Visa Gift Card - Email Submit
Enter your email address to receive a $500 Visa Gift Card when you complete our short survey.


1331 - Roomba Sweepstakes
Monthly Sweepstakes drawing. No purchase necessary for entry. Pays on first page entry form submission.


1253 -
10 free days to email other Christian singles! Enjoy 7 days free and 3 more when you post your first photo. Communicate free by email, forums, and responding to IMs. Yes, we're Christian owned and have been successfully matching Christian singles since 1999.


652 - Celeste Psychic Reading - Email Only
Celeste the Angelic Medium - request your free psychic reading now! 


728 - MoneyGram / Complete A Money Transfer - Incent
Use MoneyGram to transfer cash! Complete a money transfer with MoneyGram. Incentive OK - NO CASH INCENT!


1269 - Crypto Advantage - Multi Geo’s
Earn up to $100 per hour or more starting today Email and display traffic.


1315 - Betfaire Sports - iOS - SE
GET UP TO £/€ 100 IN FREE BETS! T&Cs Apply


1287 - VetPet Box
VetPet Box is a veterinarian owned & operated subscription service for dog and cat owners that are proactive about their pets' health and well-being and also enjoy spoiling them. Customers can choose from multiple subscription types and will receive veterinarian-selected toys, treats and wellness products delivered right to their door each month. These high-quality items are carefully selected based on the customers' provided pet profile and accompanied by monthly education materials that are fun-to-read, easy-to-understand and help customers keep their pets healthy and safe. Every month focuses on a new wellness topic such as at-home dental care, arthritis, anxiety management, heat stroke prevention and more. VetPet Boxes only contain premium quality items.


600 - Listerine Mouth Wash - Email Submit
Enter your email address and take a short survey and get a year’s supply of Listerine with a prepaid Visa Gift Card.


674 - Big Farm - Free Browser Game
The first online farm strategy game: Build your own farm, raise animals and become part of a big economic cycle. Play now for free!


1325 - Ave40 / Vape and E-cigarettes (Rev-Share)
Ave40 Affiliate Program creates opportunities for our partners to engage more deeply in the Vape communities. We offer you global reach to the most trusted online Vape sellers of Electronic Cigarettes devices, E-liquids, and other Accessories.


1293 - Pure Kratom
Kratom is widely known for improving chronic pain. Payout is 15% of entire gross sale. Average order is $60-$80 and as high as $1000.

For offer details please log into your account at